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(3S)-3-(aminomethyl)-5-methylhexanoic acid
Pregabalin is an anticonvulsant and sedative that primarily acts by binding to the alpha2-delta subunit of voltage-gated calcium channels. It modulates the release of various neurotransmitters and is used for the treatment of neuropathic pain, epilepsy, and generalized anxiety disorders. The substance has a moderate risk profile, especially when combined with other central depressants.
Class
Depressiva
Pharmacological context
Mechanism
Pregabalin ist ein Gabapentinoid – bindet selektiv an die...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: (3S)-3-(aminomethyl)-5-methyl-hexanoic acid
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Pregabalin ist ein Gabapentinoid – bindet selektiv an die α2δ-Untereinheit (Subtypen α2δ-1 und α2δ-2) spannungsgesteuerter Calciumkanäle (N-, P/Q-, L-Typ). Diese Bindung reduziert den Calciumeinstrom in erregte Neurone und hemmt dadurch die präsynaptische Ausschüttung exzitatorischer Neurotransmitter (Glutamat, Noradrenalin, Substanz P). KRITISCH: Pregabalin wirkt NICHT direkt auf GABA-Rezeptoren und hemmt NICHT GABA-Transaminase – trotz des Namens \"Gabapentinoid\". Die antikonvulsive, analgetische und anxiolytische Wirkung entsteht ausschließlich über Ca²+-Kanal-Modulation.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 150–300 mg per day
Total duration 8–12 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 75 mg per day |
| Reported | 150–300 mg per day |
| Strong | 600 mg per day |
Oral
Onset
1–2 hours
Peak
2–3 hours
Total duration
8–12 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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