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Kokain — Mechanism of Action

Pharmacological foundations and receptor profiles

StimulanzienDAT (Reuptake-Inhibitor)NET (Reuptake-Inhibitor)SERT (Reuptake-Inhibitor)Spannungsabhängige Natriumkanäle (Blocker)

Overview Effects Dosage Duration Timeline Mechanism Interactions Risks Safer Use Experiences

Mechanisms of Action

Blocks dopamine transporter (DAT) — dopamine accumulation in nucleus accumbens (primary euphoric/addictive mechanism)

Blocks serotonin transporter (SERT) — contributes to mood effects

Blocks norepinephrine transporter (NET) — sympathomimetic effects (tachycardia, hypertension)

Voltage-gated sodium channel blocker — local anesthetic action

Inhibits monoamine oxidase (MAO) — potentiates monoamine levels at high concentrations

More Information

Effects & Pharmacology
Interactions