Substances Effects Interactions Compare Community Graph Help

Laden…

⚠️ Synapedia does not replace medical advice. In case of emergency, please call 112 .Help & Resources →

Note: Synapedia is intended solely for scientific education. This platform does not provide usage instructions, dosage recommendations, or sourcing information. All content is purely informational and evidence-based.

Created by Florian Lux

Community supported

Support Synapedia

Synapedia is an independent knowledge project about psychoactive substances and harm reduction. If the platform helps you learn something new, you can support its development.

Support via PayPal Buy me a coffee

Every bit helps keep the project alive.

MDMA and tca — Interaction & Risk | Synapedia

Interaction Checker

MDMA & tca

Unvorhersehbar: Serotonerge und kardiovaskuläre Komplikationen

High Risk

Curated Data

Risk Assessment

High Risk

Trizyklische Antidepressiva hemmen die Wiederaufnahme von Serotonin und Noradrenalin und besitzen zusätzlich anticholinerge, antihistaminerge und natriumkanalblockierende Eigenschaften. In Kombination mit MDMA besteht das Risiko eines Serotoninsyndroms, schwerer Hyperthermie und kardialer Arrhythmien.