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maoi and SSRI — Interaction & Risk | Synapedia

Interaction Checker

maoi & SSRI

Absolut kontraindiziert: Schwerste Form des Serotoninsyndroms

Critical Risk

Curated Data

Risk Assessment

Critical Risk

MAOI verhindern den enzymatischen Abbau von Serotonin, während SSRI seine Wiederaufnahme blockieren. Diese doppelte Blockade führt zur maximalen Akkumulation von Serotonin im synaptischen Spalt. Dies ist eine der am besten dokumentierten lebensbedrohlichen Arzneimittelinteraktionen.

Pharmacological Mechanism

MAO-Hemmung + SERT-Blockade = maximale serotonerge Akkumulation

Substance Profiles

maoi

SSRI

Antidepressiva

Selektive Serotonin-Wiederaufnahmehemmung

SERT

Evidence Base

Curated Interaction Data

Available

Community Mentions

Shared Receptors

Sources

Gillman PK – A review of serotonin toxicity data

Safer Use Guidelines

Diese Kombination ist absolut kontraindiziert. Ein Auswaschintervall von mindestens 2 Wochen (5 Wochen bei Fluoxetin) zwischen den Substanzen ist erforderlich.