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LSD and MDMA — Interaction & Risk | Synapedia

Interaction Checker

LSD & MDMA

Verstärkte serotonerge Aktivität

Moderate Risk

Curated Data

Risk Assessment

Moderate Risk

LSD aktiviert direkt 5-HT2A-Rezeptoren, während MDMA die Serotoninfreisetzung fördert. Die Kombination kann zu einer verstärkten serotonergen Stimulation und erhöhter kardiovaskulärer Belastung führen.

Pharmacological Mechanism

5-HT2A-Agonismus + SERT-Umkehrtransport = erhöhte serotonerge Last

Substance Profiles

LSD

Psychedelika

5-HT2A-AgonistPartieller D2-Agonist

5-HT2A

5-HT1A

MDMA

Empathogene

SERT-UmkehrtransportSerotoninfreisetzung

Evidence Base

Curated Interaction Data

Available

Community Mentions

Shared Receptors

Sources

PsychonautWiki – LSD Interactions
PsychonautWiki – MDMA Interactions

Safer Use Guidelines

Die serotonerge Gesamtbelastung ist pharmakologisch erhöht; ein Serotoninsyndrom ist bei dieser Kombination seltener als bei MAO-Inhibitoren, aber nicht ausgeschlossen.