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2-(1H-indol-3-yl)ethyl-diisopropyl-amine
Diisopropyltryptamine is a substance from the class of tryptamines. Further information will follow after enrichment.
Class
Psychedelika
Pharmacological context
Mechanism
DIT (N,N-Diisopropyltryptamin, auch DiPT) ist ein Tryptamin mit...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 2-(1H-indol-3-yl)ethyl-diisopropyl-amine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
DIT (N,N-Diisopropyltryptamin, auch DiPT) ist ein Tryptamin mit ausgeprägter MAO-Resistenz durch die zwei Isopropylgruppen und besitzt das einzigartigste Wahrnehmungsprofil der Tryptamin-Familie: DIT erzeugt primär auditorische Wahrnehmungsveränderungen mit vergleichsweise geringer visueller Komponente. Diese Dissoziation zwischen auditorischen und visuellen Effekten ist für ein Tryptamin außergewöhnlich und pharmakologisch nicht vollständig erklärt. Hypothetisch wird ein höheres 5-HT2A/5-HT1A-Verhältnis im auditorischen Kortex zugrunde gelegt, möglicherweise kombiniert mit einer höheren Affinität für 5-HT2A in auditorischen Verarbeitungsarealen. Die Isopropylgruppen verleihen DIT starke MAO-Resistenz — deutlich stärker als DET — was zu zuverlässiger oraler Aktivität ohne MAOI führt (25–75 mg oral, 3–6 Stunden duration). Die ausgeprägte Körperlast (Übelkeit, gastrointestinales Unbehagen) ist das häufigste Merkmal in Erfahrungsberichten und übersteigt die von DET oder DMT. DIT wirkt als Agonist an 5-HT2A, 5-HT1A und 5-HT2C; der σ1-Rezeptor ist möglicherweise an der ungewöhnlichen sensorischen Modalitätsspezifität beteiligt.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 20–40 mg
Total duration 4–6 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 10–20 mg |
| Reported | 20–40 mg |
| Strong | 40–60 mg |
Nasal
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–20 mg |
| Strong | 20–30 mg |
Sublingual
| Tier | Dosage |
|---|---|
| Light | 5–15 mg |
| Reported | 15–30 mg |
| Strong | 30–50 mg |
Onset
30–60 minutes
Peak
1–2 hours
Total duration
4–6 hours
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
Sehr begrenzte formale Humandaten. Shulgins Selbstversuche in TIHKAL und Erfahrungsberichte.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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