Laden…
Butane-1,4-diol is a prodrug of GHB and primarily acts as a GABA-B receptor agonist. It is metabolized to GHB in the body, leading to sedative and central nervous system depressant effects. The substance has a high potential for abuse and can lead to severe adverse effects in cases of overdose.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: butane-1,4-diol
Receptor Profile
Der GABA-B-Rezeptor ist ein Gi/Go-gekoppelter metabotroper GABA-Rezeptor, der als Heterodimer (GABA-B1/B2) funktioniert. Er moduliert die Neurotransmitterfreisetzung und vermittelt langsame inhibitorische postsynaptische Potenziale.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Butane-1,4-diol is converted to GHB, which exerts its effects primarily through GABA-B receptor activation.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Dosage & Duration translation in progress
English prose is being expanded. The German version currently has more detail.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction is partially translated. Some details are still being expanded.
Risks
Summary
Atemdepression in Kombination potenziell letal. Hohes physisches und psychisches Abhängigkeitspotenzial. Entzug kann lebensbedrohlich sein (Krampfanfälle, Delir).
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interactions translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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