Laden…
Moderate Risk: Attenuated effects and uncertain risks
Chronic SSRI use can downregulate the postsynaptic 5-HT2A receptors that LSD acts on, which may reduce the psychedelic effect. Conversely, stopping an SSRI abruptly can upregulate these receptors and unexpectedly intensify the response to LSD. The risk of serotonin syndrome is lower than with MDMA and SSRIs, because LSD acts as a receptor agonist rather than triggering serotonin release, but serotonergic interactions cannot be fully excluded.
Mechanism data is language-neutral pharmacological notation.
This page is based on curated pharmacological data and/or community signals. It is intended for scientific education and harm reduction only. It does not replace professional medical advice. Not all interactions are covered — always consult a healthcare professional when in doubt. In emergencies, call your local emergency number.