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Norflurazepam

Norflurazepam is an active metabolite of flurazepam and acts as a benzodiazepine with anxiolytic, sedative, and muscle relaxant properties through modulation of the GABA-A receptor. It has a long half-life, which can lead to prolonged effects. The substance is being pharmacologically investigated for the treatment of anxiety disorders and sleep disturbances. Due to its potential for dependence and sedative effects, caution is advised.

Benzodiazepine

Mechanism of Action

  • GABA-A receptor modulation
Detailed mechanism of action

Names / Identifiers

IUPAC: Norflurazepam

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 hours
NotesDuration of action may be prolonged due to the long half-life.
Onset30-60 minutes
Total12-24 hours
After EffectsFatigue, drowsiness

Risks & Warnings

Warnings

  • Severe respiratory diseases
  • Sleep apnea
  • Pregnancy

Known Risks

  • medium
  • Mögliche Abhängigkeit und Toleranzentwicklung bei längerem Gebrauch.

Safer Use

  • Start at a low dose.
  • Do not combine with alcohol or other sedating substances.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Alcohol
  • Opioids
  • Other benzodiazepines

This list is not exhaustive. Interactions can have unpredictable effects.