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1-[1-(4-methoxyphenyl)cyclohexyl]piperidine
1-[1-(4-methoxyphenyl)cyclohexyl]piperidine (4-MeO-PCP) is a dissociative arylcyclohexylamine that primarily exerts its effects through NMDA receptor antagonism. It also shows affinity for the dopamine transporter, which may contribute to stimulating effects. The substance is mainly investigated for its dissociative and euphoric properties, with a moderate risk profile inferred from its mechanisms and adverse effects.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 1-[1-(4-methoxyphenyl)cyclohexyl]piperidine
Receptor Profile
Der NMDA-Rezeptor ist ein ionotroper Glutamatrezeptor, der eine zentrale Rolle bei synaptischer Plastizität, Lernen und Gedächtnisbildung spielt. Er benötigt sowohl Glutamat als auch Glycin als Co-Agonisten zur Aktivierung.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
4-MeO-PCP acts primarily as an NMDA receptor antagonist, influencing glutamatergic neurotransmission, and exhibits affinity for the dopamine transporter.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Dosage & Duration translation in progress
English prose is being expanded. The German version currently has more detail.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interactions translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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