Synapedia is an independent knowledge project about psychoactive substances and harm reduction. If the platform helps you learn something new, you can support its development.
Every bit helps keep the project alive.
Substance Comparison
Lachgas (Distickstoffmonoxid) stands out with markedly stronger dissociation. In terms of psychedelic depth, Lachgas (Distickstoffmonoxid) scores notably higher. Etizolam leans slightly higher in sedation.
Despite belonging to different classes, these substances share receptor activity at GABA-A, which may produce overlapping effects.
Lachgas (Distickstoffmonoxid) has significantly higher dissociation
Lachgas (Distickstoffmonoxid) has notably higher psychedelic depth
Etizolam has somewhat higher sedation
| Etizolam | Lachgas (Distickstoffmonoxid) | |
|---|---|---|
| Class | Depressiva | Dissoziativa |
| Risk Level | high | moderate |
| Mechanisms | GABA-A positive allosterische Modulation | NMDA-Antagonist, Opioid-Modulation, GABAerge Effekte |
| Receptors | GABA-A | NMDA, μ-Opioid, GABA-A |
| Effects | — | — |
| Evidence | unknown | — |
GABA-A agonist
Safer-use data available on substance page
No harm reduction data available
Evidence: unknown · Sources: 3
Evidence: not assessed · Sources: 2
Pharmacological contrast
Pharmacological contrast
Classic comparison
Pharmacological contrast
Classic comparison