Laden…
Substance Comparison
Alkohol / Ethanol stands out with markedly stronger sedation. DXM stands out with markedly stronger dissociation. In terms of addiction risk, Alkohol / Ethanol scores notably higher. In terms of psychedelic depth, DXM scores notably higher.
Despite belonging to different classes, these substances share receptor activity at NMDA, which may produce overlapping effects.
Alkohol / Ethanol has significantly higher sedation
DXM has significantly higher dissociation
Alkohol / Ethanol has notably higher addiction risk
DXM has notably higher psychedelic depth
| Alkohol / Ethanol | DXM | |
|---|---|---|
| Class | Depressiva | Dissoziativa |
| Risk Level | high | moderate |
| Mechanisms | GABA-A-Potenzierung, NMDA-Antagonismus, Endorphinfreisetzung | NMDA-Antagonist, SERT-Inhibitor, Sigma-1-Agonist |
| Receptors | GABA-A, NMDA | NMDA, SERT, Sigma-1 |
| Effects | — | Dissoziation und Loslösung vom Körper, Analgesie (Schmerzunempfindlichkeit), Euphorie und Traumzustände, Veränderte Raum- und Zeitwahrnehmung, Antidepressive Wirkung (klinisch belegt für Ketamin) |
| Evidence | — | strong |
Harm Reduction
No harm reduction data available
Evidence: not assessed · Sources: 2
Evidence: strong · Sources: 6