Synapedia

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Nicergoline

Nicergoline is an ergot alkaloid-like vasoprotective agent primarily used for the treatment of cerebral circulation disorders. It acts primarily by blocking Alpha-1 adrenergic receptors and modulating dopaminergic and serotonergic systems, leading to improved blood flow and neuroprotective effects. The substance is often used for age-related cognitive impairments. Side effects are rare but may include circulatory complaints.

Nootropika
Nootropika
Alpha-1-Adrenozeptoren
Dopaminrezeptoren
Serotoninrezeptoren

Mechanism of Action

  • Alpha-1-Adrenozeptor Blockade
  • Dopaminergische Modulation
  • Serotonergische Modulation

Names / Identifiers

IUPAC: Nicergoline

nicergoline
27848-84-6
Nicotergoline
Nimergoline
Sermion
ergobel
Nicergolina
cergodum
duracebrol
nicergolent

Mechanism of Action

Nicergoline wirkt durch die Blockade von Alpha-1-Adrenozeptoren und die Modulation dopaminerger sowie serotonerger Systeme, was zu einer verbesserten zerebralen Durchblutung führt.

Effects

Verbesserte zerebrale Durchblutung
Neuroprotektion
Erhöhung der kognitiven Leistungsfähigkeit
Verminderung von Schwindel
Reduktion von Kopfschmerzen

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 hours
NotesDuration of action may vary depending on individual metabolism.
Onset1-2 hours
Total6-8 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Pregnancy
  • Breastfeeding
  • Severe liver disease

Known Risks

  • medium
  • Mögliche Nebenwirkungen können Kopfschmerzen, Schwindel und gastrointestinale Beschwerden umfassen.

Safer Use

  • Start at a low dose
  • Be aware of interactions with other medications

Harm reduction tips do not replace medical advice.

Known Interactions

  • Antihypertensives
  • Antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USNicht zugelassen
NotesIn Deutschland, Österreich und der Schweiz ist Nicergoline verschreibungspflichtig. In den USA ist es nicht zugelassen.

Not legal advice. Status may change.