Laden…
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Naltrexone is an opioid antagonist primarily used for the treatment of opioid and alcohol dependence. It blocks the effects of opioids at the μ-, κ-, and δ-opioid receptors, thereby reducing cravings and the effects of opioids. The substance is administered orally and supports relapse prevention. Side effects are usually mild and well manageable.
Class
Not clearly classified yet
Pharmacological context
Mechanism
Opioid receptor antagonist
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Mechanism of Action
Naltrexone acts through the following pharmacological mechanisms:
Designations
IUPAC: (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 50 mg
Total duration 24 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 12 mg |
| Reported | 50 mg |
| Strong | 100 mg |
Oral
Onset
1–2 hours
Peak
3–4 hours
Total duration
24 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Kann Entzugssymptome bei opioidabhängigen Personen auslösen.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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