Laden…
(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Naltrexone is an opioid antagonist primarily used for the treatment of opioid and alcohol dependence. It blocks the effects of opioids at the μ-, κ-, and δ-opioid receptors, thereby reducing cravings and the effects of opioids. The substance is administered orally and supports relapse prevention. Side effects are usually mild and well manageable.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Mechanism of Action
Naltrexone acts through the following pharmacological mechanisms:
Designations
IUPAC: (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Total duration 24 hours
Peak
3-4 hours
Onset
1-2 hours
Total duration
24 hours
After effects
unknown
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Kann Entzugssymptome bei opioidabhängigen Personen auslösen.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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