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Evzio

Naloxone is an opioid antagonist that is primarily used for the reversal of opioid overdoses. It competitively blocks opioid receptors, particularly the μ-opioid receptor, and can rapidly negate the effects of opioids. Due to its mechanism of action, it is mainly used in emergency situations to treat respiratory depression. Naloxone has a low risk of side effects but can induce withdrawal symptoms in opioid-dependent individuals.

Opioid-Antagonisten

Mechanism of Action

  • Opioid receptor antagonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Naloxone

Narcan
Evzio
Naloxonhydrochlorid

Effects

Opioid-Antagonismus
Umkehrung von Atemdepression
Reduktion von Opioidwirkungen
Schnelle Wirkung
Wenig Nebenwirkungen

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak10-20 minutes (intravenous), 30-60 minutes (intramuscular)
NotesEffect may vary with repeated use.
Onset2-5 minutes (intravenous), 5-10 minutes (intramuscular)
Total30-90 minutes
After EffectsShort aftereffects possible, depending on the dose.

Risks & Warnings

Warnings

  • Hypersensitivity to naloxone.

Known Risks

  • low
  • Naloxon hat ein niedriges Risiko für Missbrauch und ist sicher in der Anwendung zur Umkehr von Opioid-Überdosierungen.

Safer Use

  • Always use in emergency situations.
  • Monitoring after administration is recommended.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Can negate the effects of opioids.
  • No significant interactions with other medications known.

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USRezeptfrei in vielen Bundesstaaten
NotesIn vielen Ländern ist Naloxon als Notfallmedikament zugelassen.

Not legal advice. Status may change.