Laden…
(4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Naloxone is an opioid antagonist that is primarily used for the reversal of opioid overdoses. It competitively blocks opioid receptors, particularly the μ-opioid receptor, and can rapidly negate the effects of opioids. Due to its mechanism of action, it is mainly used in emergency situations to treat respiratory depression. Naloxone has a low risk of side effects but can induce withdrawal symptoms in opioid-dependent individuals.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Naloxone acts through the following pharmacological mechanisms:
Designations
IUPAC: (4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Total duration 30-90 minutes
Peak
10-20 minutes (intravenous), 30-60 minutes (intramuscular)
Onset
2-5 minutes (intravenous), 5-10 minutes (intramuscular)
Total duration
30-90 minutes
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Naloxon hat ein niedriges Risiko für Missbrauch und ist sicher in der Anwendung zur Umkehr von Opioid-Überdosierungen.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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