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Methadone
Methadone is a synthetic opioid that primarily acts as a μ-opioid receptor agonist and is used for the treatment of chronic pain as well as in substitution therapy for opioid dependence. It has a long duration of action and can influence neuropathic pain due to its NMDA-antagonistic effect. Due to its high potential for dependence and the risk of respiratory depression, careful handling is required.
Opioide
Mechanism of Action
- NMDA antagonist
- μ-opioid receptor agonist
Names / Identifiers
IUPAC: Methadone
Dosage
Safety NoteIndividual variation, start at a low dose, no medical advice.
Individual sensitivity varies. Not a dosage recommendation.
Duration
Peak2-4 hours
NotesThe duration of action may vary depending on individual metabolism.
Onset30-60 minutes
Total24-36 hours
After Effects12-24 hours
Risks & Warnings
Warnings
- Severe respiratory diseases
- Acute abdominal pain of unknown cause
- Severe liver or kidney diseases
Known Risks
- medium
- Methadon kann zu Abhängigkeit und Überdosierung führen, insbesondere bei unsachgemäßer Anwendung.
Safer Use
- Start at a low dose.
- Regular medical check-ups.
- Avoid polydrug use with other opioids or alcohol.
Harm reduction tips do not replace medical advice.
Known Interactions
- Benzodiazepines
- Alcohol
- Other opioids
This list is not exhaustive. Interactions can have unpredictable effects.