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6-(dimethylamino)-4,4-diphenyl-heptan-3-one
Methadone is a synthetic opioid that primarily acts as a μ-opioid receptor agonist and is used for the treatment of chronic pain as well as in substitution therapy for opioid dependence. It has a long duration of action and can influence neuropathic pain due to its NMDA-antagonistic effect. Due to its high potential for dependence and the risk of respiratory depression, careful handling is required.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Mechanism of Action
Methadone acts through the following pharmacological mechanisms:
Designations
IUPAC: 6-(dimethylamino)-4,4-diphenyl-heptan-3-one
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Total duration 24-36 hours
Peak
2-4 hours
Onset
30-60 minutes
Total duration
24-36 hours
After effects
12-24 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Methadon kann zu Abhängigkeit und Überdosierung führen, insbesondere bei unsachgemäßer Anwendung.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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