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Meclizine

Meclizine is an antihistamine of the piperazine class, primarily used as an antiemetic for the treatment of nausea and dizziness. It acts by blocking H1 receptors and possesses anticholinergic properties that contribute to the alleviation of motion sickness symptoms. Due to its sedative effect, it should be used with caution, especially in combination with other central depressants.

Antihistaminika
Antihistaminika
H1-Rezeptoren
Muskarinrezeptoren

Mechanism of Action

  • anticholinerge Wirkung
  • H1-Rezeptor-Antagonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Meclizine

meclizine
Meclozine
569-65-3
Parachloramine
Navicalm
Suprimal
Vomisseis
Ravelon
Bonadettes
Sea-Legs

Mechanism of Action

Meclizine wirkt durch die Blockade von H1-Histaminrezeptoren und hat zusätzlich anticholinerge Eigenschaften, die zur Linderung von Übelkeit und Schwindel beitragen.

Effects

Antiemetisch
Sedierend
Antihistaminisch
Anticholinerg
Schwindelreduktion
Linderung von Übelkeit
Beruhigend

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-3 hours
NotesDuration of effect may vary individually.
Onset1 hour
Total6-8 hours
After Effects1-2 hours

Risks & Warnings

Warnings

  • Pregnancy and breastfeeding (consult a doctor).
  • Glaucoma and prostate hyperplasia.

Known Risks

  • medium
  • Mögliche Nebenwirkungen sind Schläfrigkeit, Mundtrockenheit und Schwindel.

Safer Use

  • Avoid alcohol and other sedating substances.
  • Do not drive if you feel drowsy.

Harm reduction tips do not replace medical advice.

Known Interactions

  • May interact with other antihistamines.
  • Caution when taken concurrently with sedatives.

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATRezeptpflichtig
CHRezeptpflichtig
DERezeptpflichtig
USRezeptfrei
NotesIn Deutschland und Österreich ist Meclizine rezeptpflichtig, während es in den USA rezeptfrei erhältlich ist.

Not legal advice. Status may change.