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Ro 5-0831

Isocarboxazid is an irreversible monoamine oxidase inhibitor (MAO inhibitor) used for the treatment of depression. It increases the availability of monoamines such as serotonin, dopamine, and norepinephrine in the synaptic cleft by inhibiting the enzyme monoamine oxidase. Due to its mechanism of action, certain dietary restrictions and interactions with other medications must be considered during use. Isocarboxazid is primarily used for treatment-resistant depressive disorders.

MAO-Hemmer

Mechanism of Action

  • Monoaminoxidase inhibitor
Detailed mechanism of action

Names / Identifiers

IUPAC: Isocarboxazid

isocarboxazid
59-63-2
Isocarboxazide
Enerzer
Marplan
Isocarbonazid
Isocarbossazide
N'-benzyl-5-methyl-1,2-oxazole-3-carbohydrazide
Isocarboxazida
Ro 5-0831

Effects

Antidepressiv
Stimmungsaufhellend
Anxiolytisch
Euphorisierend
Appetitzügelnd

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 hours
NotesEffects may last longer due to irreversible inhibition.
Onset1-2 hours
Total24 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Liver diseases
  • Pregnancy
  • Certain medications

Known Risks

  • medium
  • Mögliche Nebenwirkungen und Wechselwirkungen mit anderen Medikamenten.

Safer Use

  • Avoid foods containing tyramine.
  • Regular medical monitoring.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Tricyclic antidepressants
  • Sympathomimetics

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesIsocarboxazid ist in vielen Ländern als Medikament zur Behandlung von Depressionen zugelassen.

Not legal advice. Status may change.