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Doxepin is a tricyclic antidepressant with sedative properties that primarily acts by inhibiting the reuptake of serotonin and norepinephrine. It also possesses antagonistic effects at histamine and muscarinic acetylcholine receptors, leading to sedative and anticholinergic effects. Doxepin is therapeutically used for the treatment of depression and sleep disorders. The risk of side effects is moderate, particularly anticholinergic effects and sedation should be noted.
Class
Not clearly classified yet
Pharmacological context
Mechanism
Doxepin wirkt hauptsächlich durch die Hemmung der Wiederaufnahme von...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Mechanism of Action
Designations
IUPAC: Doxepin
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 25–75 mg
Total duration 24 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 10–25 mg |
| Reported | 25–75 mg |
| Strong | 75–150 mg |
Oral
Onset
1–3 hours
Peak
4–6 hours
Total duration
24 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Schläfrigkeit, Mundtrockenheit und Verwirrtheit.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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