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Toleranzentwicklung

Toleranzentwicklung is associated with 4 substances in experience reports.

4 mentions4 substances6 receptors

Substances with this effect

Involved Receptors & Mechanisms

Derived from receptor profiles of associated substances. Weighting is based on the frequency of substance-effect correlation.

Mechanisms of Action

Partielle Aktivität am μ-OpioidrezeptorCYP3A-vermittelte Bildung von 7-HydroxymitragyninAdrenerge Mechanismen nicht abschließend geklärtSERT-UmkehrtransportSerotoninfreisetzungNoradrenalinfreisetzung

Involved Receptors

SERTμ-Opioidrezeptorκ-Opioidrezeptoradrenerge Rezeptoren (unsicher)NETDAT

Community Data

Based on 4 mentions in verified experience reports. Not medical advice.

Most Common Substances

Kratom1x

MDMA1x

GBL1x

SSRI1x

Substance Classes

OpioideEmpathogeneDepressivaAntidepressiva

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