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Substance Comparison
Ketamin and PCP are both classified as Dissoziativa. Available data suggests they share activity at NMDA. Ketamin is commonly associated with a moderate risk profile compared to PCP.
Both substances belong to the Dissoziativa class, making this a common comparison for understanding differences within the same pharmacological family.
| Ketamin | PCP | |
|---|---|---|
| Class | Dissoziativa | Dissoziativa |
| Risk Level | moderate | high |
| Mechanisms | NMDA-Antagonist | NMDA-Antagonist, DAT-Inhibitor, Sigma-Agonist |
| Receptors | NMDA | NMDA, DAT, Sigma-1 |
| Effects | Dissoziation: Gefühl der Trennung von Körper und Umgebung (Out-of-Body-Experience), K-Hole: vollständig dissoziierter Bewusstseinszustand bei hohen Dosen, völlige Raum-Zeit-Auflösung, Starke Zeitverzerrung und veränderte Raumwahrnehmung, Analgesie: deutliche Schmerzreduktion, Halluzinationen und psychedelische Visionen | — |
| Evidence |
Ketamin wirkt hauptsächlich als Antagonist des NMDA-Rezeptors, was zu einer Hemmung der glutamatergen Neurotransmission führt und eine dissoziative Anästhesie sowie antidepressive Effekte erzeugt.
No harm reduction data available
Evidence: unknown · Sources: 2
Evidence: not assessed · Sources: 2
| unknown |
| — |