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Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Loperamid acts through the following pharmacological mechanisms:
Receptor Profile
Der μ-Opioid-Rezeptor (MOR) ist ein Gi-gekoppelter GPCR, der Analgesie, Euphorie und Atemdepression vermittelt. Er ist der primäre Zielrezeptor der meisten klinisch eingesetzten Opioide.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Risks & Harm Reduction — Translation in progress
This section is being translated. Content is available in German.
View in German →The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
QT-Verlängerung und kardiale Risiken bei Hochdosis-Kombination
Loperamid ist ein peripherer μ-Opioid-Agonist (nicht ZNS-gängig in therapeutischen Dosen). In Hochdosis (>100 mg), wie sie beim missbräuchlichen Gebrauch zur Opioid-Substitution vorkommt, überwindet Loperamid die Blut-Hirn-Schranke, wirkt zentral opioidartig und blockiert hERG-Kaliumkanäle. Die Kombination mit anderen Opioiden potenziert beide Risiken.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.