Snri — Drug Interactions

Known pharmacological interactions based on scientific literature

7 interactions

This information is based on scientific literature and is for educational purposes only. It does not replace medical advice.

sub:maoiCritical Risk

Dangerous interaction risk

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

MAO-Hemmung (Serotonin/NA/DA-Abbau blockiert) + SERT/NET-Blockade (SNRI, Wiederaufnahme blockiert) = vollständige Elimination der Serotonin- UND Noradrenalin-ClearanceSNRI addieren zum serotonergen Risiko der reinen SSRI-MAOI-Interaktion noch eine noradrenerge Krise (hypertensiver Notfall) über NET-Blockade

Gillman PK – MAOI interactions and serotonin toxicity

Boyer EW & Shannon M – The serotonin syndrome

MDMAHigh Risk

Dangerous interaction risk

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

SERT-Umkehrtransport (MDMA) + SERT/NET-Blockade (SNRI) = serotonerge und noradrenerge Überaktivierung

Gillman PK – Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity EMCDDA – MDMA Drug Profile

DMTHigh Risk

Dangerous interaction risk

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

5-HT2A/5-HT1A-Agonismus + MAO-A-Substrat (DMT) + chronische SERT/NET-Blockade (SNRI) = erhöhte serotonerge Exposition bei verzögertem DMT-AbbauSNRI verlangsamen über CYP2D6-Inhibition (einige SNRI wie Duloxetin) den DMT-Metabolismus — pharmakokinetische Interaktion

Callaway JC & Grob CS – Ayahuasca pharmacology Stahl SM – SNRI pharmacology

5-MeO-DMTHigh Risk

Dangerous interaction risk

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

Potente 5-HT1A/5-HT2A-Agonismus + MAO-Substrat (5-MeO-DMT) + SERT/NET-Blockade (SNRI) = serotonerge Krise möglich5-MeO-DMT hat ein höheres serotoninerges Risikoprofil als DMT oder LSD — die SNRI-Interaktion ist entsprechend relevanter

Sklerov J et al. – Death associated with 5-MeO-DMT Stahl SM – SNRI pharmacology

DXMHigh Risk

Dangerous interaction risk

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

SERT-Inhibition + Sigma-1-Agonismus (DXM) + SERT/NET-Blockade (SNRI) = dreifach konvergierende serotonerge HemmungDXM und SNRI konkurrieren am SERT — die additive SERT-Blockade erhöht das Serotoninsyndrom-Risiko klinisch relevant

FDA Drug Safety Communication – Serotonin syndrome with DXM Boyer EW & Shannon M – Serotonin syndrome

TramadolHigh Risk

High Risk: Serotonin Syndrome and Seizures

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

SERT/NET-Inhibition + Krampfschwellensenkung + μ-Opioid-Agonismus (Tramadol) + SERT/NET-Blockade (SNRI) = doppelte serotonerge/noradrenerge Hemmung + erniedrigte KrampfschwelleTramadol und SNRI hemmen beide SERT und NET — die pharmakokinetische Überlappung erhöht Serotoninsyndrom- und Krampfrisiko synergistisch

Gillman PK – Tramadol, serotonin toxicity FDA – Tramadol Drug Safety Communication

LSDModerate Risk

Caution-level interaction risk

Detailed interaction narrative is still being translated. This card shows the available risk level, mechanism tags, sources, and data provenance only.

Mechanism

5-HT2A-Agonismus (LSD) + chronische SERT/NET-Blockade (SNRI) = 5-HT2A-Rezeptor-Downregulation durch chronisch erhöhtes SerotoninSNRI-bedingte Noradrenalinerhöhung kann die sympathomimetische LSD-Komponente (Tachykardie, Mydriasis, Tremor) verstärken

Bonson KR et al. – Chronic SSRI/SNRI and LSD response Stahl SM – SNRI mechanism of action

Interaction Checker

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