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Esketamine
Esketamine is a dissociative anesthetic and NMDA receptor antagonist, primarily used in the treatment of treatment-resistant depression. It acts quickly as an antidepressant and differs from the racemate ketamine due to its higher affinity for the NMDA receptor. Side effects may include dissociative states and increased blood pressure. The substance is used under medical supervision and carries moderate risks with improper use.
Dissoziativa
Mechanism of Action
- NMDA receptor antagonist
Names / Identifiers
IUPAC: Esketamine
Dosage
Safety NoteIndividual variation, start at a low dose, no medical advice.
Individual sensitivity varies. Not a dosage recommendation.
Duration
Peak30 minutes
NotesEffect may vary depending on dose and route of administration.
Onset5-10 minutes
Total1-2 hours
After Effects1-2 hours
Risks & Warnings
Warnings
- Severe cardiovascular diseases
- Schizophrenia
Known Risks
- medium
- Mögliche Nebenwirkungen umfassen Schwindel, Übelkeit und dissoziative Symptome.
Safer Use
- Start at a low dose
- Avoid polydrug use
- Monitoring in a safe environment
Harm reduction tips do not replace medical advice.
Known Interactions
- Benzodiazepines
- Alcohol
- Opioids
This list is not exhaustive. Interactions can have unpredictable effects.