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Diphenhydramine

Diphenhydramine is a first-generation antihistamine with sedative and anticholinergic properties. It blocks H1 receptors and muscarinic acetylcholine receptors, leading to calming effects and antiallergic action. Due to its anticholinergic effects, it can cause side effects such as confusion and hallucinations in case of overdose. The substance is commonly used to treat allergies, sleep disorders, and motion sickness.

Antihistaminika

Mechanism of Action

  • H1-Rezeptor-Antagonist
  • muskarinerge Acetylcholinrezeptor-Antagonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Diphenhydramine

Mechanism of Action

Diphenhydramine wirkt als Antagonist am H1-Histaminrezeptor und hat zusätzlich anticholinerge Eigenschaften, die zur Sedierung beitragen.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak1-2 hours
NotesDuration may vary depending on dosage and individual response.
Onset15-30 minutes
Total4-6 hours
After Effects2-4 hours

Risks & Warnings

Warnings

  • Glaucoma
  • Prostate hyperplasia
  • Cardiovascular diseases

Known Risks

  • medium
  • Kann sedierende Effekte und anticholinerge Nebenwirkungen hervorrufen.

Safer Use

  • Dose low to minimize side effects.
  • Do not combine with alcohol or other sedating substances.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Alcohol
  • Benzodiazepines
  • Opioids

This list is not exhaustive. Interactions can have unpredictable effects.