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Desipramine

Desipramine is a tricyclic antidepressant that primarily inhibits the reuptake of norepinephrine, thereby having a mood-lifting effect. It is used for the treatment of depression and exhibits a side effect profile that includes anticholinergic effects. The substance affects various neurotransmitter systems and can pose risks if misused.

Antidepressiva

Mechanism of Action

  • Norepinephrine reuptake inhibitor
  • SERT inhibitor
Detailed mechanism of action

Names / Identifiers

IUPAC: Desipramine

Mechanism of Action

Desipramin wirkt hauptsächlich als Hemmer der Wiederaufnahme von Noradrenalin und Serotonin, was zu einer Erhöhung der Verfügbarkeit dieser Neurotransmitter im synaptischen Spalt führt.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak4-6 weeks
NotesThe effect may build up over several weeks.
Onset1-2 weeks
Total24 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Heart diseases
  • Glaucoma
  • Pregnancy

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen anticholinerge Effekte, Gewichtszunahme und Sedierung.

Safer Use

  • Regular medical monitoring
  • Slow dose adjustment

Harm reduction tips do not replace medical advice.

Known Interactions

  • MAO inhibitors
  • Alcohol
  • other antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.