Synapedia
Back to substances
Deutsch|English

Translated automatically – community improvements welcome.

Clotiapine

Clotiapine is an atypical antipsychotic from the group of thienobenzodiazepines, which primarily acts through its antagonistic effect on dopamine D2 and serotonin 5-HT2A receptors. It is used for the treatment of schizophrenia and other psychotic disorders. The substance has sedative properties and can cause side effects such as extrapyramidal symptoms. Due to its pharmacological profile, careful medical supervision is required.

Antipsychotika

Mechanism of Action

  • 5-HT2A antagonist
  • D2 antagonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Clotiapine

Mechanism of Action

Clotiapine wirkt als atypisches Antipsychotikum, indem es die Aktivität von Dopamin und Serotonin im Gehirn moduliert.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-6 hours
NotesDuration of action may vary depending on individual metabolism.
Onset1-2 hours
Total24 hours
After Effects12-24 hours

Risks & Warnings

Warnings

  • Known hypersensitivity to Clotiapine
  • Severe liver or kidney disease

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen Sedierung, Gewichtszunahme und extrapyramidale Symptome.

Safer Use

  • Regular medical supervision
  • Slow dose adjustment
  • Avoidance of alcohol and other sedatives

Harm reduction tips do not replace medical advice.

Known Interactions

  • Increased sedative effect with alcohol
  • Interactions with other antipsychotics

This list is not exhaustive. Interactions can have unpredictable effects.