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Clonidine

Clonidine is an alpha-2 adrenergic receptor agonist primarily used for lowering blood pressure. It acts by inhibiting noradrenergic signaling in the central nervous system and can also be used to treat withdrawal symptoms. The substance has sedative properties and affects the autonomic nervous system.

Antihypertensiva

Mechanism of Action

  • Alpha-2 adrenergic agonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Clonidine

Mechanism of Action

Clonidin wirkt als Agonist an Alpha-2-Adrenozeptoren im zentralen Nervensystem, was zu einer Hemmung der Noradrenalinfreisetzung führt und eine sedierende Wirkung entfaltet.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 hours
NotesDuration of action may vary depending on the route of administration.
Onset1-2 hours
Total8-12 hours
After EffectsFatigue, drowsiness

Risks & Warnings

Warnings

  • Severe heart diseases
  • Renal insufficiency

Known Risks

  • medium
  • Mögliche Nebenwirkungen sind Schläfrigkeit, Mundtrockenheit und Blutdruckabfall.

Safer Use

  • Start at a low dose
  • Regular blood pressure monitoring
  • Avoid alcohol and sedatives

Harm reduction tips do not replace medical advice.

Known Interactions

  • MAO inhibitors
  • Benzodiazepines
  • Alcohol

This list is not exhaustive. Interactions can have unpredictable effects.