Translated automatically – community improvements welcome.
Amitriptyline
Amitriptyline is a tricyclic antidepressant that primarily works by inhibiting the reuptake of serotonin and norepinephrine. It also possesses antagonistic effects at various receptors, leading to sedative and anticholinergic effects. The substance is used not only for the treatment of depression but also for pain therapy. Due to its side effect profile and toxic potential in overdose, a moderate risk profile should be considered.
Mechanism of Action
- NET inhibitor
- SERT inhibitor
Names / Identifiers
IUPAC: Amitriptyline
Mechanism of Action
Amitriptylin wirkt hauptsächlich durch die Hemmung der Wiederaufnahme von Serotonin und Noradrenalin in die präsynaptischen Neuronen, was zu einer erhöhten Verfügbarkeit dieser Neurotransmitter im synaptischen Spalt führt.
Effects
Effects described from scientific sources. Individual experiences vary.
Dosage
Individual sensitivity varies. Not a dosage recommendation.
Duration
Risks & Warnings
Warnings
- Pregnancy
- Heart diseases
- Glaucoma
Known Risks
- medium
- Mögliche Nebenwirkungen umfassen Sedierung, anticholinerge Effekte und kardiovaskuläre Risiken.
Safer Use
- Start at a low dose
- Regular medical check-ups
- Avoid alcohol and other sedatives
Harm reduction tips do not replace medical advice.
Known Interactions
- MAO inhibitors
- Alcohol
- Benzodiazepines
This list is not exhaustive. Interactions can have unpredictable effects.
Legal Status
Not legal advice. Status may change.